. The actinomycetes. Actinomycetales. DESCRIPTIONS OF ANTIBIOTICS 169 Table 38 Percentage of actinomycins contained in various mixtures (62, 77)" Mixture Actinomycin I II Ill IV V VI'' VII A type tr.^ B type tr. tr. C'' type D type tr. tr. tr. tr. X'' type ' V " See references to "Actinomycins," Part A. * Roussos and Vining (62) described a VI component in the "B type" mixture, but this is not synony lous with the VI of Waksman et al. (77). ' tr. = trace. ?^ other minor components not
. The actinomycetes. Actinomycetales. DESCRIPTIONS OF ANTIBIOTICS 169 Table 38 Percentage of actinomycins contained in various mixtures (62, 77)" Mixture Actinomycin I II Ill IV V VI'' VII A type tr.^ B type tr. tr. C'' type D type tr. tr. tr. tr. X'' type ' V " See references to "Actinomycins," Part A. * Roussos and Vining (62) described a VI component in the "B type" mixture, but this is not synony lous with the VI of Waksman et al. (77). ' tr. = trace. ?^ other minor components not listed in the table. ' Probably represents X^ + Xoa + another less well defined fraction. ?'? Contains other major and minor components not listed in the CH, The polypeptide portions of the various actino- mycins contain a variety of amino acids differing in their identity, arrangement, and number. Physical and chemical variations observed be- tween various components appear to be caused by these differences. To date, all actinomycins de- scribed contain L-threonine and sarcosine (Table 39). The complete structures of actinomycins I to VII are shown below, and some of their properties are given in Table 40 (44, 57, 63, 65, 95, 101). —L-valine-N—CH3 N—CHrL-valine—, sarcosine sarcosine A B C D -L-threonine L-threonine- CO. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Waksman, Selman A. (Selman Abraham), 1888-1973. Baltimore, Williams & Wilkins
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