. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. PARASITES 357 â¢^, lifi!. mm experimentateurs connaissent parfaitement les alterations de degene rescence et d'infiltration qu'on rencontre constamment dans les reins atteints de coccidiose, afin de ne pas mettre en relation ces phenomenes avec d'autres causes etrangeres au coccidium qui n'est pas toujours bien reconnaissable, qui n'est pas toujours reconnu et qui, pour le passe, a constitue souvent une cause d'; This statement could well be broadened to include the other organs infected


. Biology of the laboratory mouse. Mice as laboratory animals; Mice; Animals, Laboratory; Mice. PARASITES 357 â¢^, lifi!. mm experimentateurs connaissent parfaitement les alterations de degene rescence et d'infiltration qu'on rencontre constamment dans les reins atteints de coccidiose, afin de ne pas mettre en relation ces phenomenes avec d'autres causes etrangeres au coccidium qui n'est pas toujours bien reconnaissable, qui n'est pas toujours reconnu et qui, pour le passe, a constitue souvent une cause d'; This statement could well be broadened to include the other organs infected by the parasite. Sarcosporidia Sarcocystis muris blanchard.âThis was the first species of Sarcocystis to be described, having been discovered by Meischer in 1843, infecting the muscle of mice. Since that time it has been found in the rat, and other species have been found infecting various other animals. However, the most extensive studies have been with S. muris since its hosts can be easily infected by feeding them infected tissue. These parasites (Fig. 139) can be seen as tiny white streaks known as iVIeischer's tubes" imbedded in striated muscle tissue or less commonly in non- striated muscle. The tubes may be as much as 5 cm. long or they may be so small as to be seen only with the microscope. They are filled with sickle- shaped spores called "Rainey's cor- ; When the spores are ingested by the host a small amoeboid body is liberated which penetrates the epithelial cells of the intestine. Here schizogony occurs producing merozoites which make their way to the muscle tissue where after about forty days multinucleated plasmodia can be found. Cells may be liberated and reinfect other muscle fibers until an intense infection is reached. Ultimately development progresses to form the Meischer's tubes containing the spores. In some cases no serious results are apparent with the infection, although death of mice occurs with heavy infection. It has been s


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