. Ciba Foundation symposium on drug resistance in micro-organisms: mechanisms of development. Drug resistance in microorganisms. Physiological Mechanisms of Resistanxe 171 p-aminobenzoic acid (PAB) and j9-hydroxybenzoic acid (POB) (Fig. 2). As is well known, PAB utilization is competitively inhibited by analogues in which the carboxyl is replaced by a substituted or unsubstituted sulphonamide group. Similar competition between POB and its sulphonamide analogues was observed. Furthermore, p-nitrobenzoic acid (PNB), an. •Fig. 2. Schematic representation of competition by analogues of PAB and POB
. Ciba Foundation symposium on drug resistance in micro-organisms: mechanisms of development. Drug resistance in microorganisms. Physiological Mechanisms of Resistanxe 171 p-aminobenzoic acid (PAB) and j9-hydroxybenzoic acid (POB) (Fig. 2). As is well known, PAB utilization is competitively inhibited by analogues in which the carboxyl is replaced by a substituted or unsubstituted sulphonamide group. Similar competition between POB and its sulphonamide analogues was observed. Furthermore, p-nitrobenzoic acid (PNB), an. •Fig. 2. Schematic representation of competition by analogues of PAB and POB. X = 2-thiazolylamino. (Reproduced by permission of University of Chicago Press.) analogue involving replacement at the other end of the molecule (amino or hydroxyl), competes with both vitamins. It was observed that mutants resistant to PNB competition with either vitamin were not altered in respect to its competition with the other vitamin. Furthermore, with either vitamin there was no crossresistance between PNB competition and sulphonamide competition. Without presenting in detail the arguments involved or the subsidiary evidence (cf. Davis and Maas, 1952), I should like to summarize by stating that this. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation; Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
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