. Control of ovulation; proceedings of the conference held at Endicott House, Dedham, Massachusetts, 1960. Ovulation -- Regulation. 178 Discussions of a persistent corpus in these animals was ruled out by examining the ovaries at laparotomy and later, at autopsy. Accordingly, in eight ewes the behavioral manifesta- tions of heat were abolished by hspothalamic lesions, presumably without affecting pituitary gonadotropin secretion. The area destroyed by the lesions in se%en of these animals is shown in Fig. 1. Part of the brain of the other sheep was inadsertently destroyed, so detailed localiza
. Control of ovulation; proceedings of the conference held at Endicott House, Dedham, Massachusetts, 1960. Ovulation -- Regulation. 178 Discussions of a persistent corpus in these animals was ruled out by examining the ovaries at laparotomy and later, at autopsy. Accordingly, in eight ewes the behavioral manifesta- tions of heat were abolished by hspothalamic lesions, presumably without affecting pituitary gonadotropin secretion. The area destroyed by the lesions in se%en of these animals is shown in Fig. 1. Part of the brain of the other sheep was inadsertently destroyed, so detailed localization was not possible. The se\en lesions were in the basal ponion of the h>pothalamus, sharing in common an area of destruction just in front of the infundibulum and above the median eminence. Lesions in other pans of the h>pothalamus in 17 animals had no effect on either ovarian cycling or heat. The areas of destruction in these sheep are showTi in Fig. 2. It is apparent that extensive lesions in the diencephalon did not affect sexual behavior. SITES OF HYPOTHALAMIC LESWNS K 17 EWES WITH HCfiVAL HEAT PERIODS AND CYCUC OVARIES. :£5'=7r£D BYLE30NS Fig. 2. Indeed, in a number of instances, ewes with control lesions accepted the male less than 24 hr postoperatively, while still staggering from the effects of the pentobarbital anesthesia. Therefore, the data indicate that the effect of lesions on sexual behavior is specific, and depends on a reasonably discrete area in the anterior h>pothalamus. The idea of a diencephalic centre concerned with sexual behavior is, of course, not new. Dempsey and Rioch (/. Neurophysiol. 2, 9, 1939j and Bard (Res. Publ. Assn. Nerv. Ment. Dis. 20, 551, 1940) originally presented evidence for such a centre by comparing the sexual responses of decorticate and decerebrate guinea-pigs and cats. Subsequently, Brookhart and his associates (Endocrinology 28, 561, 1941) obser\ed absence of mating behavior in female guinea-pigs with anterior hvpoihal
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