Ferroptosis, illustration. Ferroptosis is an iron-dependent form of programmed cell death caused by the peroxidation (free radical-mediated damage, bottom right) of phospholipids in the cell membrane. Cells are usually protected against peroxidation by the selenium (SE, red spheres)-dependent enzyme glutathione peroxidase 4 (GPX4, orange). Inhibitors of GPX4 lead to the accumulation of damage and trigger cell death.

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Photo credit: © NICOLLE R. FULLER/SCIENCE PHOTO LIBRARY / Alamy / Afripics
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