. The elements of pathological histology with special reference to practical methods . life show similar retrograde changes to cartilage, viz.,fibrillation, amyloid degeneration, and deposit of lime. 358 THE OSSEOUS SYSTEM 2. Regenerative and Hyperplastic Processes.—The regeneration ofosseous tissue, as it takes place after fractures, resections, and the like,always commences from the periosteum and the marrow, and followsthe type of the physiological development of bone. In simplefractures it is only in the first few days that the regenerative pro-cesses are accompanied by inflammatory change
. The elements of pathological histology with special reference to practical methods . life show similar retrograde changes to cartilage, viz.,fibrillation, amyloid degeneration, and deposit of lime. 358 THE OSSEOUS SYSTEM 2. Regenerative and Hyperplastic Processes.—The regeneration ofosseous tissue, as it takes place after fractures, resections, and the like,always commences from the periosteum and the marrow, and followsthe type of the physiological development of bone. In simplefractures it is only in the first few days that the regenerative pro-cesses are accompanied by inflammatory changes, which are incon-siderable in degree and consist partly in the outpouring of fluidexudation into the injured tissues (the bone-marrow, the periosteum,and the adjoining soft parts), and partly in the immigration ofleucocytes in moderately large numbers, which take up the detritusof* tissue left by the lesion, together with the extravasated blood, andconvey them away. The principal changes, however, are the regener-ative, which begin with growth of the cells of the marrow on the. Fig. 179.—Development of Bone from the Periostkum. x 285. (Alum cochineal.)a, Outer layer of periosteum, containing few cells ; 6, Inner (osteoplastic) layer, rich in cells ;c, Osteoblasts; d, Osteoid tissue. ^ one hand {internal callus), and of the periosteum and partly also ofthe immediately adjoining soft parts on the other {external callus).In the periosteum it is especially the inner {osteoplastic) layer(Fig. 179, h) in which the connective-tissue cells and those of theendothelium lining the vessels are engaged in proliferation by karyo-kinesis, and thus produce a highly vascular tissue, composed oflargish cells of variable shape embedded in a homogeneous interstitialsubstance. By this means, as well as by the simultaneous growthof the cells of the marrow, there results an extensive absorption ofthe bone at the broken ends and a smoothing of the latter. Later,however, the new tissue in the per
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Keywords: ., bookcentury1800, bookdecade1890, booksubjectpatholo, bookyear1895
