. MORBID ANATOMY 325 alcoholic material and gave expression to the belief that the disease was caused by a fungus. Fish, in 1896, found a fungus embedded in the diseased tissue. He did not name it neither did he obtain it in pure cul- ture, but his illustrations are ver3' clear in showing the existence of the fungus. Fish gives in detail the methods he employed. It is to his work that we are indebted for the more careful description of the morbid changes. Fig. 80. A piece from the lip of an affected horse, shozv- § 248. Morbid anatomy. As i"g' several diseased foci a rule the lesions are
. MORBID ANATOMY 325 alcoholic material and gave expression to the belief that the disease was caused by a fungus. Fish, in 1896, found a fungus embedded in the diseased tissue. He did not name it neither did he obtain it in pure cul- ture, but his illustrations are ver3' clear in showing the existence of the fungus. Fish gives in detail the methods he employed. It is to his work that we are indebted for the more careful description of the morbid changes. Fig. 80. A piece from the lip of an affected horse, shozv- § 248. Morbid anatomy. As i"g' several diseased foci a rule the lesions are near the (-^"''^)- surface. Where the diseased portion has become well de- veloped there is usually a more or less complete detachment of the central inflammatory growth from the surrounding tissue. This nodular or "kunker" growth may vary in its density according to the stage of its development. During the early stages it is soft and easily cut; later it becomes firmer and ultimately assumes a hard or "gritty" character. In cutting sections it is generally the exception to cut through the nodule or kunker evenly and to have it retain its proper relations with the other parts. Even if successful in cutting, the nodule drops out after some of the other processes. In the specimens examined the lesions were confined entirely to the skin and subcutaneous ; no traces of muscular or glandular structure were observed. Around the central por- tion of the inflammatory growth there is a zone of leucocytes of the mononuclear and polynuclear varieties, the latter pre- dominating. They are embedded in an abundant stroma of connective tissue which is in a greater or less stage of degen- eration. The central portion of the zone is in some cases very closely packed with the leuococytes, while toward the peri- phery they are more loosely arranged and cause a marked irregularity of the margin from their uneven drifting into the tissue beyond. There is generally
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