Archives of internal medicine . used were provided by Dr. Isaac Levin of the Eocke-feller Institute, by the Department of Health of the Cii:y of New Yorkand by the Saranac Laboratory. Two frogs were so arranged that the capillary blood-flow in the uri-nary bladder-wall could be watched through a microscope fitted with amicrometer eye-piece. To each was given 1 of ether in five equaldoses in the dorsal lymph-sac. In the ether given to one was dissolved1 mg. of bacillary fat extracted from the dry tubercle powder. In thecourse of an hour and a half, at the end of which time both frogs died,
Archives of internal medicine . used were provided by Dr. Isaac Levin of the Eocke-feller Institute, by the Department of Health of the Cii:y of New Yorkand by the Saranac Laboratory. Two frogs were so arranged that the capillary blood-flow in the uri-nary bladder-wall could be watched through a microscope fitted with amicrometer eye-piece. To each was given 1 of ether in five equaldoses in the dorsal lymph-sac. In the ether given to one was dissolved1 mg. of bacillary fat extracted from the dry tubercle powder. In thecourse of an hour and a half, at the end of which time both frogs died,the capillaries of the frog which received ether alone were chiefly smalland blanched, while, the other one showed marked dilatation of the capil-laries, an increase of 25 per cent, in the caliber of the small vessels havingoccurred. To reason from a single observation on cold-blooded animalsas to conditions in human beings would not he justified, but what evi-dence there was pointed to a vasodilator effect. HA YEN EMERHO^ 451. CO g o .2 -a ^ (1; cS CO C t^ .5 452 THE ARCHIVES OE l\TEh\AL MEDKISE An etherized dog was then used, and continuous graphic records ofrespiration by pleural cannula, and blood-pressure by mercury manom-eter and membrane manometer were made, while various doses of etlierand a solution of bacillary fat or wax of the tubercle bacillus were givenbv the jugular and femoral veins. Although the ether solution of the bacillary fat appeared to depressthe blood-pressure and relax the arterial tone for a much longer periodthan did an equal dose of ether alone, still the effect of the fat was notsufficiently striking to be free from doubt. An etherized cat was then used and records made as in the previousexperiment. Barillen-Emulsion was then injected intravenously in dosesfrom mg. to 5 mg. of solid substance. Following this, old tuber-culin was used in doses from 1 mg. to mg. of solid substance. Lastlysolutions of mannite culture of tubercle bacillus in
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